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Target identification in small cell lung cancer via integrated phenotypic screening and activity-based protein profiling

To overcome hurdles in identifying key kinases in small cell lung cancer (SCLC), we integrated a target-agnostic phenotypic screen of kinase inhibitors with target identification using activity-based protein profiling (ABPP) in which a desthiobiotin-ATP probe was used. We screened 21 SCLC cell lines...

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Detalles Bibliográficos
Publicado en:Mol Cancer Ther
Main Authors: Li, Jiannong, Fang, Bin, Kinose, Fumi, Bai, Yun, Kim, Jae-Young, Chen, Ann, Rix, Uwe, Koomen, John M., Haura, Eric B.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747823/
https://ncbi.nlm.nih.gov/pubmed/26772203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0444
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