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Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
Inactivation of the von Hippel-Lindau (VHL) gene is associated with the development of highly vascularized tumors. pVHL targets the α-subunits of Hypoxia Inducible Factor (HIF) for ubiquitin-mediated degradation in an oxygen-dependent manner. Although pVHL-deficient tumor cell lines demonstrate cons...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4120823/ https://ncbi.nlm.nih.gov/pubmed/12559177 |
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