Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

Inactivation of the von Hippel-Lindau (VHL) gene is associated with the development of highly vascularized tumors. pVHL targets the α-subunits of Hypoxia Inducible Factor (HIF) for ubiquitin-mediated degradation in an oxygen-dependent manner. Although pVHL-deficient tumor cell lines demonstrate cons...

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Hlavní autoři: Mack, Fiona A., Rathmell, W. Kimryn, Arsham, Andrew M., Gnarra, James, Keith, Brian, Simon, M. Celeste
Médium: Artigo
Jazyk:Inglês
Vydáno: 2003
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120823/
https://ncbi.nlm.nih.gov/pubmed/12559177
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