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X-inactivation normalizes O-GlcNAc transferase levels and generates an O-GlcNAc-depleted Barr body

O-GlcNAc Transferase (OGT) catalyzes protein O-GlcNAcylation, an abundant and dynamic nuclear and cytosolic modification linked to epigenetic regulation of gene expression. The steady-state levels of O-GlcNAc are influenced by extracellular glucose concentrations suggesting that O-GlcNAcylation may...

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Detalhes bibliográficos
Main Authors: Olivier-Van Stichelen, Stéphanie, Hanover, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120696/
https://ncbi.nlm.nih.gov/pubmed/25136351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00256
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