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Nutrient-driven O-linked N-acetylglucosamine (O-GlcNAc) cycling impacts neurodevelopmental timing and metabolism

Nutrient-driven O-GlcNAcylation is strikingly abundant in the brain and has been linked to development and neurodegenerative disease. We selectively targeted the O-GlcNAcase (Oga) gene in the mouse brain to define the role of O-GlcNAc cycling in the central nervous system. Brain knockout animals exh...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Olivier-Van Stichelen, Stephanie, Wang, Peng, Comly, Marcy, Love, Dona C., Hanover, John A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5391740/
https://ncbi.nlm.nih.gov/pubmed/28246173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.774042
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