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Mutation of the Little Finger Domain in Human DNA Polymerase η Alters Fidelity When Copying Undamaged DNA

DNA polymerase η (pol η) synthesizes past cyclobutane pyrimidine dimer and possibly 7,8-dihydro-8-oxoguanine (8-oxoG) lesions during DNA replication. Loss of pol η is associated with an increase in mutation rate, demonstrating its indispensable role in mutation suppression. It has been recently repo...

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Bibliografiska uppgifter
Huvudupphovsmän: Beardslee, Renee A., Suarez, Samuel C., Toffton, Shannon M., McCulloch, Scott D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120640/
https://ncbi.nlm.nih.gov/pubmed/23913529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.21807
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