Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor

ERBB3/HER3 expression and signaling is upregulated in mutant BRAF melanoma as an adaptive, pro-survival response to FDA-approved RAF inhibitors. Since compensatory ERBB3 signaling counteracts the effects of RAF inhibitors, co-targeting ERBB3 may increase the efficacy of RAF inhibitors in mutant BRAF...

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Bibliographic Details
Main Authors: Kugel, Curtis H., Hartsough, Edward J., Davies, Michael A., Setiady, Yulius Y., Aplin, Andrew E.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120074/
https://ncbi.nlm.nih.gov/pubmed/25035390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0464
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