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Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor
ERBB3/HER3 expression and signaling is upregulated in mutant BRAF melanoma as an adaptive, pro-survival response to FDA-approved RAF inhibitors. Since compensatory ERBB3 signaling counteracts the effects of RAF inhibitors, co-targeting ERBB3 may increase the efficacy of RAF inhibitors in mutant BRAF...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4120074/ https://ncbi.nlm.nih.gov/pubmed/25035390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0464 |
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