Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

The mechanisms underlying adaptive resistance of melanoma to targeted therapies remain unclear. By combining ChIP sequencing with microarray-based gene profiling, we determined that ERBB3 is upregulated by FOXD3, a transcription factor that promotes resistance to RAF inhibitors in melanoma. Enhanced...

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Bibliografiska uppgifter
Huvudupphovsmän: Abel, Ethan V., Basile, Kevin J., Kugel, Curtis H., Witkiewicz, Agnieszka K., Le, Kaitlyn, Amaravadi, Ravi K., Karakousis, Giorgos C., Xu, Xiaowei, Xu, Wei, Schuchter, Lynn M., Lee, Jason B., Ertel, Adam, Fortina, Paolo, Aplin, Andrew E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635724/
https://ncbi.nlm.nih.gov/pubmed/23543055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65780
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