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Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma
BACKGROUND: Current therapies for metastatic melanoma are targeted either at cancer mutations driving growth (e.g., vemurafenib) or immune-based therapies (e.g., ipilimumab). Tumour progression also requires angiogenesis, which is regulated by VEGF-A, itself alternatively spliced to form two familie...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4119992/ https://ncbi.nlm.nih.gov/pubmed/25010863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.342 |
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