Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma

BACKGROUND: Current therapies for metastatic melanoma are targeted either at cancer mutations driving growth (e.g., vemurafenib) or immune-based therapies (e.g., ipilimumab). Tumour progression also requires angiogenesis, which is regulated by VEGF-A, itself alternatively spliced to form two familie...

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Библиографические подробности
Главные авторы: Gammons, M V, Lucas, R, Dean, R, Coupland, S E, Oltean, S, Bates, D O
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
Предметы:
Translational Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119992/
https://ncbi.nlm.nih.gov/pubmed/25010863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.342
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