A thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primates

A long-acting, thermostable bacterial cocaine esterase (CocE) has been identified that rapidly degrades cocaine with a K(M) of 1.33+0.085 μM. In vivo evaluation of CocE has shown protection against convulsant and lethal effects of cocaine in rodents, confirming the therapeutic potential of CocE agai...

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Detalhes bibliográficos
Main Authors: Howell, L L, Nye, J A, Stehouwer, J S, Voll, R J, Mun, J, Narasimhan, D, Nichols, J, Sunahara, R, Goodman, M M, Carroll, F I, Woods, J H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119218/
https://ncbi.nlm.nih.gov/pubmed/24984194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2014.48
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