The Prolyl Peptidases PRCP/PREP Regulate IRS-1 Stability Critical for Rapamycin-induced Feedback Activation of PI3K and AKT

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/AKT)/mammalian target of rapamycin (mTOR) pathway conveys signals from receptor tyrosine kinases (RTKs) to regulate cell metabolism, proliferation, survival, and motility. Previously we found that prolylcarboxypeptidase (PRCP) regulate p...

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Detalles Bibliográficos
Main Authors: Duan, Lei, Ying, Guoguang, Danzer, Brian, Perez, Ricardo E., Shariat-Madar, Zia, Levenson, Victor V., Maki, Carl G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118128/
https://ncbi.nlm.nih.gov/pubmed/24936056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550038
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