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Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?

In the aging brain, the correct balance of neural transmission and its regulation is of particular significance, and neuropeptides have a significant role. Prolyl oligopeptidase (PREP) is a protein highly expressed in brain, and evidence indicates that it is related to aging and in neurodegenration....

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Männistö, Pekka T., García-Horsman, J. Arturo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5306367/
https://ncbi.nlm.nih.gov/pubmed/28261087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00027
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