Structural basis of the methylation specificity of R.DpnI

R.DpnI consists of N-terminal catalytic and C-terminal winged helix domains that are separately specific for the Gm6ATC sequences in Dam-methylated DNA. Here we present a crystal structure of R.DpnI with oligoduplexes bound to the catalytic and winged helix domains and identify the catalytic domain...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mierzejewska, Karolina, Siwek, Wojciech, Czapinska, Honorata, Kaus-Drobek, Magdalena, Radlinska, Monika, Skowronek, Krzysztof, Bujnicki, Janusz M., Dadlez, Michal, Bochtler, Matthias
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2014
Pynciau:
Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117772/
https://ncbi.nlm.nih.gov/pubmed/24966351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku546
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