Conjugation with polyamines enhances the antibacterial and anticancer activity of chloramphenicol

Chloramphenicol (CAM) is a broad-spectrum antibiotic, limited to occasional only use in developed countries because of its potential toxicity. To explore the influence of polyamines on the uptake and activity of CAM into cells, a series of polyamine–CAM conjugates were synthesized. Both polyamine ar...

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Detalhes bibliográficos
Main Authors: Kostopoulou, Ourania N., Kouvela, Ekaterini C., Magoulas, George E., Garnelis, Thomas, Panagoulias, Ioannis, Rodi, Maria, Papadopoulos, Georgios, Mouzaki, Athanasia, Dinos, George P., Papaioannou, Dionissios, Kalpaxis, Dimitrios L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117768/
https://ncbi.nlm.nih.gov/pubmed/24939899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku539
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