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Effect of polyamines on the inhibition of peptidyltransferase by antibiotics: revisiting the mechanism of chloramphenicol action

Chloramphenicol is thought to interfere competitively with the binding of the aminoacyl-tRNA 3′-terminus to ribosomal A-site. However, noncompetitive or mixed-noncompetitive inhibition, often observed to be dependent on chloramphenicol concentration and ionic conditions, leaves some doubt about the...

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Detalhes bibliográficos
Main Authors: Xaplanteri, Maria A., Andreou, Athanasios, Dinos, George P., Kalpaxis, Dimitrios L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC212793/
https://ncbi.nlm.nih.gov/pubmed/12930958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg686
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