Effect of polyamines on the inhibition of peptidyltransferase by antibiotics: revisiting the mechanism of chloramphenicol action

Chloramphenicol is thought to interfere competitively with the binding of the aminoacyl-tRNA 3′-terminus to ribosomal A-site. However, noncompetitive or mixed-noncompetitive inhibition, often observed to be dependent on chloramphenicol concentration and ionic conditions, leaves some doubt about the...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Xaplanteri, Maria A., Andreou, Athanasios, Dinos, George P., Kalpaxis, Dimitrios L.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2003
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212793/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12930958/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg686
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