Integrated RNA and DNA sequencing improves mutation detection in low purity tumors

Identifying somatic mutations is critical for cancer genome characterization and for prioritizing patient treatment. DNA whole exome sequencing (DNA-WES) is currently the most popular technology; however, this yields low sensitivity in low purity tumors. RNA sequencing (RNA-seq) covers the expressed...

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Detalhes bibliográficos
Main Authors: Wilkerson, Matthew D., Cabanski, Christopher R., Sun, Wei, Hoadley, Katherine A., Walter, Vonn, Mose, Lisle E., Troester, Melissa A., Hammerman, Peter S., Parker, Joel S., Perou, Charles M., Hayes, D. Neil
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117748/
https://ncbi.nlm.nih.gov/pubmed/24970867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku489
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