Integrated RNA and DNA sequencing improves mutation detection in low purity tumors

Identifying somatic mutations is critical for cancer genome characterization and for prioritizing patient treatment. DNA whole exome sequencing (DNA-WES) is currently the most popular technology; however, this yields low sensitivity in low purity tumors. RNA sequencing (RNA-seq) covers the expressed...

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Detalles Bibliográficos
Autores principales: Wilkerson, Matthew D., Cabanski, Christopher R., Sun, Wei, Hoadley, Katherine A., Walter, Vonn, Mose, Lisle E., Troester, Melissa A., Hammerman, Peter S., Parker, Joel S., Perou, Charles M., Hayes, D. Neil
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
Materias:
Methods Online
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117748/
https://ncbi.nlm.nih.gov/pubmed/24970867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku489
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