Integrated RNA and DNA sequencing improves mutation detection in low purity tumors

Identifying somatic mutations is critical for cancer genome characterization and for prioritizing patient treatment. DNA whole exome sequencing (DNA-WES) is currently the most popular technology; however, this yields low sensitivity in low purity tumors. RNA sequencing (RNA-seq) covers the expressed...

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Bibliographische Detailangaben
Hauptverfasser: Wilkerson, Matthew D., Cabanski, Christopher R., Sun, Wei, Hoadley, Katherine A., Walter, Vonn, Mose, Lisle E., Troester, Melissa A., Hammerman, Peter S., Parker, Joel S., Perou, Charles M., Hayes, D. Neil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
Schlagworte:
Methods Online
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117748/
https://ncbi.nlm.nih.gov/pubmed/24970867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku489
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