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Proteasome Inhibitors Alter Levels of Intracellular Peptides in HEK293T and SH-SY5Y Cells

The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of human embryonic kidney 293T (HEK293T) cells with epoxomicin (an irreversible proteasome inhibitor) generally caused a decrease in levels of intracellular peptides. However, bortezomib (an antitumor d...

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Detalhes bibliográficos
Main Authors: Dasgupta, Sayani, Castro, Leandro M., Dulman, Russell, Yang, Ciyu, Schmidt, Marion, Ferro, Emer S., Fricker, Lloyd D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117522/
https://ncbi.nlm.nih.gov/pubmed/25079948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103604
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