Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

Triggering of the Fas/APO-1 cell-surface receptor induces apoptosis through an uncharacterized chain of events. Exposure of Fas-sensitive cells to an agonist monoclonal antibody induced cell death and a 200-300% elevation in endogenous levels of the sphingolipid ceramide, a proposed intracellular me...

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Autores principales: Tepper, C G, Jayadev, S, Liu, B, Bielawska, A, Wolff, R, Yonehara, S, Hannun, Y A, Seldin, M F
Formato: Artigo
Lenguaje:Inglês
Publicado: 1995
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC41173/
https://ncbi.nlm.nih.gov/pubmed/7545303
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