Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

Triggering of the Fas/APO-1 cell-surface receptor induces apoptosis through an uncharacterized chain of events. Exposure of Fas-sensitive cells to an agonist monoclonal antibody induced cell death and a 200-300% elevation in endogenous levels of the sphingolipid ceramide, a proposed intracellular me...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Tepper, C G, Jayadev, S, Liu, B, Bielawska, A, Wolff, R, Yonehara, S, Hannun, Y A, Seldin, M F
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41173/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7545303/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.18.8443
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