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The amino-terminal peptide of Bax perturbs intracellular Ca(2+) homeostasis to enhance apoptosis in prostate cancer cells

During apoptosis, proteolytic cleavage of Bax at the amino terminus generates a truncated Bax of ∼18 kDa (p18Bax) and an amino-terminal peptide of ∼3 kDa (p3Bax). Whereas extensive studies have shown that p18Bax behaves like a BH3 protein with enhanced pro-apoptotic function over that of the full-le...

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Bibliografiska uppgifter
Huvudupphovsmän: Li, Na, Lin, Peihui, Cai, Chuanxi, Pan, Zui, Weisleder, Noah, Ma, Jianjie
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2009
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116348/
https://ncbi.nlm.nih.gov/pubmed/19091958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00390.2008
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