Uncoupling Store-Operated Ca(2+) Entry and Altered Ca(2+) Release from Sarcoplasmic Reticulum through Silencing of Junctophilin Genes

Junctophilin (JP) mediates the close contact between cell surface and intracellular membranes in muscle cells ensuring efficient excitation-contraction coupling. Here we demonstrate that disruption of triad junction structure formed by the transverse tubular (TT) invagination of plasma membrane and...

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Detalhes bibliográficos
Main Authors: Hirata, Yutaka, Brotto, Marco, Weisleder, Noah, Chu, Yi, Lin, Peihui, Zhao, Xiaoli, Thornton, Angela, Komazaki, Shinji, Takeshima, Hiroshi, Ma, Jianjie, Pan, Zui
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2006
Assuntos:
Channels, Receptors, and Electrical Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1471867/
https://ncbi.nlm.nih.gov/pubmed/16565048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.076570
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