Hepatocyte Produced Matrix Metalloproteinases Are Regulated by CD147 in Liver Fibrogenesis

BACKGROUND: The classical paradigm of liver injury asserts that hepatic stellate cells (HSC) produce, remodel and turnover the abnormal extracellular matrix (ECM) of fibrosis via matrix metalloproteinases (MMPs). In extrahepatic tissues MMP production is regulated by a number of mechanisms including...

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Autori principali: Calabro, Sarah R., Maczurek, Annette E., Morgan, Alison J., Tu, Thomas, Wen, Victoria W., Yee, Christine, Mridha, Auvro, Lee, Maggie, d'Avigdor, William, Locarnini, Stephen A., McCaughan, Geoffrey W., Warner, Fiona J., McLennan, Susan V., Shackel, Nicholas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116334/
https://ncbi.nlm.nih.gov/pubmed/25076423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090571
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