Hepatocyte Produced Matrix Metalloproteinases Are Regulated by CD147 in Liver Fibrogenesis

BACKGROUND: The classical paradigm of liver injury asserts that hepatic stellate cells (HSC) produce, remodel and turnover the abnormal extracellular matrix (ECM) of fibrosis via matrix metalloproteinases (MMPs). In extrahepatic tissues MMP production is regulated by a number of mechanisms including...

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Autors principals: Calabro, Sarah R., Maczurek, Annette E., Morgan, Alison J., Tu, Thomas, Wen, Victoria W., Yee, Christine, Mridha, Auvro, Lee, Maggie, d'Avigdor, William, Locarnini, Stephen A., McCaughan, Geoffrey W., Warner, Fiona J., McLennan, Susan V., Shackel, Nicholas A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116334/
https://ncbi.nlm.nih.gov/pubmed/25076423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090571
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