Hepatocyte Produced Matrix Metalloproteinases Are Regulated by CD147 in Liver Fibrogenesis

BACKGROUND: The classical paradigm of liver injury asserts that hepatic stellate cells (HSC) produce, remodel and turnover the abnormal extracellular matrix (ECM) of fibrosis via matrix metalloproteinases (MMPs). In extrahepatic tissues MMP production is regulated by a number of mechanisms including...

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Detalhes bibliográficos
Main Authors: Calabro, Sarah R., Maczurek, Annette E., Morgan, Alison J., Tu, Thomas, Wen, Victoria W., Yee, Christine, Mridha, Auvro, Lee, Maggie, d'Avigdor, William, Locarnini, Stephen A., McCaughan, Geoffrey W., Warner, Fiona J., McLennan, Susan V., Shackel, Nicholas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116334/
https://ncbi.nlm.nih.gov/pubmed/25076423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090571
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