Interferon Regulatory Factor-5 Deficiency Ameliorates Disease Severity in the MRL/lpr Mouse Model of Lupus in the Absence of a Mutation in DOCK2

Interferon regulatory factor 5 (IRF5) polymorphisms are strongly associated with an increased risk of developing the autoimmune disease systemic lupus erythematosus. In mouse lupus models, IRF5-deficiency was shown to reduce disease severity consistent with an important role for IRF5 in disease path...

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Main Authors: Yasuda, Kei, Watkins, Amanda A., Kochar, Guneet S., Wilson, Gabriella E., Laskow, Bari, Richez, Christophe, Bonegio, Ramon G., Rifkin, Ian R.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116215/
https://ncbi.nlm.nih.gov/pubmed/25076492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0103478
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