Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.

Congenic MRL-lpr mice homozygous and heterozygous for the IFN-gamma gene disruption were created to assess the role of this pleotropic cytokine on the lymphoaccumulation and lupus-like disease of Fas-defective mice. Early death was prevented, and glomerulonephritis severely reduced in IFN-gamma-/- m...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Balomenos, D, Rumold, R, Theofilopoulos, A N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1998
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508575/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9435308/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI750
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