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Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.
Congenic MRL-lpr mice homozygous and heterozygous for the IFN-gamma gene disruption were created to assess the role of this pleotropic cytokine on the lymphoaccumulation and lupus-like disease of Fas-defective mice. Early death was prevented, and glomerulonephritis severely reduced in IFN-gamma-/- m...
Sparad:
| I publikationen: | J Clin Invest |
|---|---|
| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Clinical Investigation
1998
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508575/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9435308/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI750 |
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