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Intratumor heterogeneity alters most effective drugs in designed combinations

The substantial spatial and temporal heterogeneity observed in patient tumors poses considerable challenges for the design of effective drug combinations with predictable outcomes. Currently, the implications of tissue heterogeneity and sampling bias during diagnosis are unclear for selection and su...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhao, Boyang, Hemann, Michael T., Lauffenburger, Douglas A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115561/
https://ncbi.nlm.nih.gov/pubmed/25002493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323934111
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