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Intratumor heterogeneity alters most effective drugs in designed combinations
The substantial spatial and temporal heterogeneity observed in patient tumors poses considerable challenges for the design of effective drug combinations with predictable outcomes. Currently, the implications of tissue heterogeneity and sampling bias during diagnosis are unclear for selection and su...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4115561/ https://ncbi.nlm.nih.gov/pubmed/25002493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323934111 |
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