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Commensal microbes drive intestinal inflammation by IL-17–producing CD4(+) T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2
The costimulatory B7-1 (CD80)/B7-2 (CD86) molecules, along with T-cell receptor stimulation, together facilitate T-cell activation. This explains why in vivo B7 costimulation neutralization efficiently silences a variety of human autoimmune disorders. Paradoxically, however, B7 blockade also potentl...
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| Main Authors: | , , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
National Academy of Sciences
2014
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4115533/ https://ncbi.nlm.nih.gov/pubmed/25002484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402336111 |
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