Cyclin-Dependent Kinase 5 Mediates Adult OPC Maturation and Myelin Repair through Modulation of Akt and GsK-3β Signaling

Failure of remyelination in diseases, such as multiple sclerosis (MS), leads to permanent axonal damage and irreversible functional loss. The mechanisms controlling remyelination are currently poorly understood. Recent studies implicate the cyclin-dependent kinase 5 (Cdk5) in regulating oligodendroc...

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Autores principales: Luo, FuCheng, Burke, Kathryn, Kantor, Christopher, Miller, Robert H., Yang, Yan
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4115145/
https://ncbi.nlm.nih.gov/pubmed/25080600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0710-14.2014
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