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Function and regulation of the Rho guanine nucleotide exchange factor Trio
Rho GTPases oscillate between an inactive GDP-bound state and an active GTP-bound state. They are activated by Rho Guanine nucleotide Exchange Factors (GEF), which accelerate the GDP to GTP exchange. RhoGEFs fall into two different classes: the Dbl family and the DOCK family of proteins. In this rev...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4114922/ https://ncbi.nlm.nih.gov/pubmed/24987837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.29769 |
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