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The many faces of the guanine-nucleotide exchange factor trio

Small Rho-GTPases are enzymes that are bound to GDP or GTP, which determines their inactive or active state, respectively. The exchange of GDP for GTP is catalyzed by so-called Rho-guanine nucleotide exchange factors (GEFs). Rho-GEFs are characterized by a Dbl-homology (DH) and adjacent Pleckstrin-h...

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Bibliografiske detaljer
Main Authors: van Rijssel, Jos, van Buul, Jaap D.
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547891/
https://ncbi.nlm.nih.gov/pubmed/23076143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cam.21418
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