Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.

We report here that the activation of the interleukin 1 beta (IL-1 beta)-converting enzyme (ICE) family is likely to be one of the crucial events of tumor necrosis factor (TNF) cytotoxicity. The cowpox virus CrmA protein, a member of the serpin superfamily, inhibits the enzymatic activity of ICE and...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Miura, M, Friedlander, R M, Yuan, J
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41148/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7667287/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.18.8318
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