Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.
We report here that the activation of the interleukin 1 beta (IL-1 beta)-converting enzyme (ICE) family is likely to be one of the crucial events of tumor necrosis factor (TNF) cytotoxicity. The cowpox virus CrmA protein, a member of the serpin superfamily, inhibits the enzymatic activity of ICE and...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1995
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41148/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7667287/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.18.8318 |
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