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The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4α
CYP3A4 (cytochrome P450 3A4) is involved in the metabolism of more than 50 % of drugs and other xenobiotics. The expression of CYP3A4 is induced by many structurally dissimilar compounds. The PXR (pregnane X receptor) is recognized as a key regulator for the induction, and the PXR-directed transacti...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4114763/ https://ncbi.nlm.nih.gov/pubmed/17764444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070613 |
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