DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes

In this study, we provided molecular evidences that IL-6 contributed to the decreased capacity of oxidative biotransformation in human liver by suppressing the expression of CYP3A4. After human hepatocytes were treated with IL-6, DEC1 expression rapidly increased, and subsequently, the CYP3A4 expres...

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Hoofdauteurs: Zhao, Mao, Xiaofei, Luan, Gang, Cao, Wei, Liu, Jing, Xiong, Gang, Hu, Ruini, Chen, Rui, Ning, Wei, Shang, Jian, Yang, Bingfang, Yan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4088276/
https://ncbi.nlm.nih.gov/pubmed/22728071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.06.010
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