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Downregulation of DEC1 contributes to the neurotoxicity induced by MPP (+) by suppressing PI3K/Akt/GSK3β pathway

AIM: Differentiated embryonic chondrocyte gene 1 (DEC1) is involved in the neuronal differentiation and development. The aim of this study is to investigate the role of DEC1 in 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPP (+))‐induced PD model. METHODS: The location of DEC1 and tyrosine hydroxy...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Zhu, Zhu, Wang, Yu‐Wen, Ge, Ding‐Hao, Lu, Ming, Liu, Wei, Xiong, Jing, Hu, Gang, Li, Xiao‐Ping, Yang, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492752/
https://ncbi.nlm.nih.gov/pubmed/28734031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12717
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