RanBP9 Overexpression Accelerates Loss of Dendritic Spines in a Mouse Model of Alzheimer's Disease

We previously demonstrated that RanBP9 overexpression increased Aβ generation and amyloid plaque burden, subsequently leading to robust reductions in the levels of several synaptic proteins as well as deficits in the learning and memory skills in a mouse model of Alzheimer's disease (AD). In th...

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Autori principali: Wang, Ruizhi, Palavicini, Juan Pablo, Wang, Hongjie, Maiti, Panchanan, Bianchi, Elisabetta, Xu, Shaohua, Lloyd, BN, Dawson-Scully, Ken, Kang, David E, Lakshmana, Madepalli K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113832/
https://ncbi.nlm.nih.gov/pubmed/24892886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.05.029
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