COPS5 (Jab1) Protein Increases β Site Processing of Amyloid Precursor Protein and Amyloid β Peptide Generation by Stabilizing RanBP9 Protein Levels

Increased processing of amyloid precursor protein (APP) and accumulation of neurotoxic amyloid β peptide (Aβ) in the brain is central to the pathogenesis of Alzheimer's disease (AD). Therefore, the identification of molecules that regulate Aβ generation is crucial for future therapeutic approac...

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Detalles Bibliográficos
Main Authors: Wang, Hongjie, Dey, Debleena, Carrera, Ivan, Minond, Dmitriy, Bianchi, Elisabetta, Xu, Shaohua, Lakshmana, Madepalli K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772213/
https://ncbi.nlm.nih.gov/pubmed/23926111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476689
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