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RanBP9 Overexpression Accelerates Loss of Pre and Postsynaptic Proteins in the APΔE9 Transgenic Mouse Brain

There is now compelling evidence that the neurodegenerative process in Alzheimer’s disease (AD) begins in synapses. Loss of synaptic proteins and functional synapses in the amyloid precursor protein (APP) transgenic mouse models of AD is well established. However, what is the earliest age at which s...

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Detalhes bibliográficos
Main Authors: Wang, Hongjie, Wang, Ruizhi, Xu, Shaohua, Lakshmana, Madepalli K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891818/
https://ncbi.nlm.nih.gov/pubmed/24454876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085484
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