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Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation

Integrin α5β1 is essential for vascular development but it remains unclear precisely where and how it functions. Here, we report that deletion of the gene encoding the integrin-α5 subunit [Itga5] using the Pdgfrb-Cre transgenic mouse line, leads to oedema, haemorrhage and increased levels of embryon...

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Bibliografske podrobnosti
Main Authors: Turner, Christopher J., Badu-Nkansah, Kwabena, Crowley, Denise, van der Flier, Arjan, Hynes, Richard O.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113717/
https://ncbi.nlm.nih.gov/pubmed/24858485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2014.05.006
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