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Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation

Integrin α5β1 is essential for vascular development but it remains unclear precisely where and how it functions. Here, we report that deletion of the gene encoding the integrin-α5 subunit [Itga5] using the Pdgfrb-Cre transgenic mouse line, leads to oedema, haemorrhage and increased levels of embryon...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Turner, Christopher J., Badu-Nkansah, Kwabena, Crowley, Denise, van der Flier, Arjan, Hynes, Richard O.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113717/
https://ncbi.nlm.nih.gov/pubmed/24858485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2014.05.006
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