Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease of insidious onset, and is responsible for up to 30,000 deaths per year in the U.S. Excessive production of extracellular matrix by myofibroblasts has been shown to be an important pathological feature in IPF. TGF-β1 is express...

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Hlavní autoři: Luo, Fayong, Zhuang, Yan, Sides, Mark D, Sanchez, Cecilia G, Shan, Bin, White, Eric S, Lasky, Joseph A
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113202/
https://ncbi.nlm.nih.gov/pubmed/24762191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-15-51
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