Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease of insidious onset, and is responsible for up to 30,000 deaths per year in the U.S. Excessive production of extracellular matrix by myofibroblasts has been shown to be an important pathological feature in IPF. TGF-β1 is express...

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Main Authors: Luo, Fayong, Zhuang, Yan, Sides, Mark D, Sanchez, Cecilia G, Shan, Bin, White, Eric S, Lasky, Joseph A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113202/
https://ncbi.nlm.nih.gov/pubmed/24762191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-15-51
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