Epidithiodiketopiperazines (ETPs) exhibit in vitro antiangiogenic and in vivo antitumor activity by disrupting the HIF-1α/p300 complex in a preclinical model of prostate cancer

The downstream targets of hypoxia inducible factor-1 alpha (HIF-1α) play an important role in tumor progression and angiogenesis. Therefore, inhibition of HIF-mediated transcription has potential in the treatment of cancer. One attractive strategy for inhibiting HIF activity is the disruption of the...

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Hauptverfasser: Reece, Kelie M, Richardson, Emily D, Cook, Kristina M, Campbell, Tessa J, Pisle, Stephen T, Holly, Alesia J, Venzon, David J, Liewehr, David J, Chau, Cindy H, Price, Douglas K, Figg, William D
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113146/
https://ncbi.nlm.nih.gov/pubmed/24775564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-91
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