Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction

Inhibition of the hypoxia-inducible factor 1α (HIF-1α) pathway by disrupting its association with the transcriptional coactivator p300 inhibits angiogenesis and tumor development. Development of HIF-1α/p300 inhibitors has been hampered by preclinical toxicity; therefore, we aimed to identify novel H...

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Publicado no:J Nat Prod
Main Authors: Goey, Andrew K. L., Chau, Cindy H., Sissung, Tristan M., Cook, Kristina M., Venzon, David J., Castro, Amaya, Ransom, Tanya R., Henrich, Curtis J., McKee, Tawnya C., McMahon, James B., Grkovic, Tanja, Cadelis, Melissa M., Copp, Brent R., Gustafson, Kirk R., Figg, William D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323635/
https://ncbi.nlm.nih.gov/pubmed/27140429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jnatprod.5b00846
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