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PAS Kinase Drives Lipogenesis Through SREBP-1 Maturation
Elevated hepatic synthesis of fatty acids and triglycerides, driven by hyperactivation of the SREBP-1c transcription factor, has been implicated as a causal feature of the metabolic syndrome. SREBP-1c activation requires the proteolytic maturation of the endoplasmic reticulum-bound precursor to the...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4112965/ https://ncbi.nlm.nih.gov/pubmed/25001282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.006 |
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