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PAS Kinase Drives Lipogenesis Through SREBP-1 Maturation

Elevated hepatic synthesis of fatty acids and triglycerides, driven by hyperactivation of the SREBP-1c transcription factor, has been implicated as a causal feature of the metabolic syndrome. SREBP-1c activation requires the proteolytic maturation of the endoplasmic reticulum-bound precursor to the...

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Détails bibliographiques
Auteurs principaux: Wu, Xiaoying, Romero, Donna, Swiatek, Wojciech I., Dorweiler, Irene, Kikani, Chintan K., Sabic, Hana, Zweifel, Ben S., McKearn, John, Blitzer, Jeremy T., Nickols, G. Allen, Rutter, Jared
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112965/
https://ncbi.nlm.nih.gov/pubmed/25001282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.06.006
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