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ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis
Cyclin D1 deregulation is implicated in the genesis of multiple human cancers. Importantly, nuclear cyclin D1 retention during S-phase promotes DNA re-replication and subsequent genomic instability, providing a direct correlation between aberrant cyclin D1/CDK4 activity, transcriptional regulation a...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4112739/ https://ncbi.nlm.nih.gov/pubmed/23318439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.577 |
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