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A rationale to target the SWI/SNF complex for cancer therapy
SWI/SNF is a multi-subunit chromatin remodeling complex that performs fundamental roles in gene regulation, cell lineage specification, and organismal development. Mutations that inactivate SWI/SNF subunits are found in nearly 20% of human cancers, which indicates that the proper functioning of this...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4112150/ https://ncbi.nlm.nih.gov/pubmed/24932742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2014.05.001 |
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